Redox Biology

Principal Investigator

H. Susana Marinho
Assistant Professor, PhD Universidade de Lisboa (1995)

Research

The Redox Biology group research focuses on hydrogen peroxide (H₂O₂), the main cellular oxidant now considered a key redox regulator. The long-term goal is to understand signalling pathways and molecular mechanisms by which H₂O₂ regulates physiological processes that, when unbalanced, lead to disease. This is one of the main objectives defined for the CQB’s strategic area entitled Human Health: Molecular Interventions and Regulation Mechanisms.

The group expects to establish quantitative and cause/effect relationships between H₂O₂ levels and regulation of gene expression, organelle dynamics and disease. These studies will allow identifying molecular targets of H₂O₂ with possible therapeutic use in diseases, such as cancer and inflammation, and in aging.