H. Susana Marinho
Assistant Professor, PhD Universidade de Lisboa (1995)
The Redox Biology group research focuses on hydrogen peroxide (H2O2), the main cellular oxidant now considered a key redox regulator. The long-term goal is to understand signalling pathways and molecular mechanisms by which H2O2 regulates physiological processes that, when unbalanced, lead to disease. This is one of the main objectives defined for the CQB’s strategic area entitled Human Health: Molecular Interventions and Regulation Mechanisms.
The group expects to establish quantitative and cause/effect relationships between H2O2 levels and regulation of gene expression, organelle dynamics and disease. These studies will allow identifying molecular targets of H2O2 with possible therapeutic use in diseases, such as cancer and inflammation, and in aging.